Hydrochloric Acid → 5-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride

HRID 84765Notes

Reaction equation

HRID 84765 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:21][O:20][C:17]1[CH:16]=[N:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:19][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86686610HCID 86686610, compound

Product 1

HCID 866866095-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

953 mg 4-(5-methoxy-pyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester was stirred in 16 mL 4 mol/L HCl solution in dioxane for 45 min The precipitate was filtered, washed with dioxane and dried to yield 723 mg of the desired compound.

Workup

  1. filtrationwas filtered
  2. washwashed with dioxane
  3. customdried

Sources & evidence

ORD record
ord-52544c2fe5bf477186804ede906a41fd
Source dataset
uspto-grants-2014_09
Patent number
US08846948B2

Reaction notes

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