Hydrochloric Acid → HCID 12833269, compound

HRID 848033Notes

Reaction equation

HRID 848033 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([N-:12][C:13](=[O:19])[CH2:14][CH2:15][CH2:16][CH2:17]Cl)[C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10])([O-:3])=[O:2].[OH-].[Na+].Cl>O1CCCC1.O>[N+:1]([C:4]1[CH:5]=[C:6]([N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C:13]2=[O:19])[C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10])([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178425652HCID 178425652, compound

Product 1

HCID 12833269HCID 12833269, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

77 g (0.27 mol) of N-(3-nitro-4,6-dimethylphenyl)-δ-chlorovaleroylamide are stirred vigorously in a mixture of 50 ml of tetrahydrofurane and 500 ml of 22% strength aqueous sodium hydroxide solution for 5 hours at 60°-65°. The reaction mixture is diluted with water, cooled and acidified with hydrochloric acid. The product which has precipitated is washed until neutral and dried in a desiccator at 70°. This gives 62.8 g (93%); melting point 134°-135°.

Workup

  1. temperaturecooled
  2. customThe product which has precipitated
  3. washis washed until neutral and
  4. customdried in a desiccator at 70°

Sources & evidence

ORD record
ord-e862bdff8c934715940641ec00b668c6
Source dataset
uspto-grants-1981_10
Patent number
US04294606

Reaction notes

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