Hydrochloric Acid → MLS002667383

HRID 848161Notes

Reaction equation

HRID 848161 reaction equation
[OH-:1].[Na+].O[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=[O:20])=[CH:15][CH:14]=1.Cl>C(O)C>[OH:1][C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:5](=[O:6])[CH2:4][CH:19]([C:16]1[CH:17]=[CH:18][N:13]=[CH:14][CH:15]=1)[OH:20]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 133894-PyridinecarboxaldehydeHCID 14798Sodium HydroxideHCID 68490alpha-Hydroxyacetophenone

Product 1

HCID 242178MLS002667383

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the method of Corvaisier (Bull. Soc. Chim. Fr. 1962, 528) 15 ml of an 11 N aqueous sodium hydroxide solution are added to a solution of 24 g of 2-hydroxyacetophenone and 21 g of pyridine-4-carbaldehyde in 130 ml of absolute ethanol maintained an ambient temperature. An abundant yellow precipitate forms at first which then gradually dissolves. After two hours at ambient temperature the mixture is adjusted to pH 1 by means of hydrochloric acid. The yellow precipitate obtained is filtered, washed with water and dried. 27 g of 1-(2-hydroxyphenyl) 3-(4-pyridyl) 3-hydroxy 1-propanone melting at 150° C. are obtained.

Workup

  1. dissolutionAn abundant yellow precipitate forms at first which then gradually dissolves
  2. customThe yellow precipitate obtained
  3. filtrationis filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-469f2215b931479dae9e1401e36ce6dc
Source dataset
uspto-grants-1981_10
Patent number
US04294841

Reaction notes

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