4'-Fluoroacetophenone → HCID 53830815, compound

HRID 848163Notes

Reaction equation

HRID 848163 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1)=[O:3].[N:11]1[CH:16]=[CH:15][C:14]([CH:17]=O)=[CH:13][CH:12]=1.[OH-].C[N+](C)(C)C.[OH-].[Na+]>CO>[F:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH:1]=[CH:17][C:14]2[CH:15]=[CH:16][N:11]=[CH:12][CH:13]=2)=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 98284'-FluoroacetophenoneHCID 133894-PyridinecarboxaldehydeHCID 14798Sodium HydroxideHCID 60966Tetramethylammonium hydroxide

Product 1

HCID 53830815HCID 53830815, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure is as in Example 11 starting from 2.9 g of 4-fluoroacetophenone and 3 g of pyridine-4-carbaldehyde, but using a solution of tetramethylammonium hydroxide in methanol instead of the aqueous solution of sodium hydroxide. 1-(4-fluorophenyl) 3-(4-pyridyl) 2-propene-1-one which melts at 157° C. is obtained.

Sources & evidence

ORD record
ord-e057ccec77f0409fada9753a1699ad43
Source dataset
uspto-grants-1981_10
Patent number
US04294841

Reaction notes

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