Methanol → HCID 54267340, compound

HRID 848165Notes

Reaction equation

CO[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[N:12]1[CH:17]=[CH:16][C:15]([CH:18]=O)=[CH:14][CH:13]=1.[OH-:20].[Na+].[CH3:22]O>>[CH3:22][O:20][C:11]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:4](=[O:5])[CH:3]=[CH:18][C:15]1[CH:14]=[CH:13][N:12]=[CH:17][CH:16]=1

Participants

Reactant 4

HCID 887Methanol

HCID 133894-Pyridinecarboxaldehyde

HCID 14798Sodium Hydroxide

HCID 776982-Methoxy-1-phenylethanone

Product 1

HCID 54267340HCID 54267340, compound

Procedure

The procedure is as in Example 11, starting from 15 g of 2-methoxyacetophenone and 20.4 g of pyridine-4-carbaldehyde in 50 ml of methanol and using 45 ml of a 2.5 N aqueous sodium hydroxide solution in place of the 11 N solution. 7 g of 1-(2-methoxyphenyl) 3-(4-pyridyl) 2-propene-1-one which melts at 70° C. are obtained.

Sources & evidence

ORD record: ord-7a23613ecdcd48d3b236ee4155a61aba
Source dataset: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04294841

Reaction notes

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