Benzene → HCID 54574710, compound

HRID 848175Notes

Reaction equation

HRID 848175 reaction equation
C1([N:7]=[C:8]=[S:9])C=CC=CC=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][CH2:18][C:19]1[N:23]=[CH:22][O:21][N:20]=1.[CH:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[O:21]1[CH:22]=[N:23][C:19]([CH2:18][S:17][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:8]([NH2:7])=[S:9])=[N:20]1

Participants

4

Reactant 3

HCID 241Benzene2×HCID 7673Phenyl IsothiocyanateHCID 3057622Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

Product 1

HCID 54574710HCID 54574710, compound

Procedure

Phenylisothiocyanate (1.31 g) in benzene (10 ml) was added dropwise to a stirred solution of 3-(2-aminophenylthiomethyl)-1,2,4-oxadiazole (20 g) in benzene (10 ml). The resultant solution was refluxed for 3 hours, the solvent removed by evaporation under reduced pressure to give a solid which was re-crystallised from isopropanol to give N-[2-(1,2,4-oxadiazol-3-yl-methylthio)phenyl]-N1 -phenylthiourea, m.p. 128°.

Workup

  1. customthe solvent removed by evaporation under reduced pressure
  2. customto give a solid which
  3. customwas re-crystallised from isopropanol

Sources & evidence

ORD record
ord-ad9cc6f0cfa249b9affa35ee5724286c
Source dataset
uspto-grants-1981_10
Patent number
US04294843

Reaction notes

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