Methyl Isocyanate → HCID 20566616, compound

HRID 848224Notes

Reaction equation

HRID 848224 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([Cl:9])[CH:3]=1.[CH3:10][N:11]=[C:12]=[O:13]>C(OC(=O)C)C>[Cl:9][C:4]1[CH:3]=[C:2]([NH:1][C:12]([NH:11][CH3:10])=[O:13])[CH:7]=[CH:6][C:5]=1[OH:8]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 775784-Amino-2-chlorophenol

Product 1

HCID 20566616HCID 20566616, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4 -amino-2-chlorophenol (21.5 g; 0.15 mol) in ethylacetate (400 ml) is cooled to 0° C. and then methyl isocyanate (18.6 g; 0.15 mol) added slowly. The solution is stirred for one hour and then evaporated under vacuum to afford 30 g of title product, m.p. 188°-189° C.

Workup

  1. customevaporated under vacuum

Sources & evidence

ORD record
ord-a6afcc2e87764f1a9ce8be1b6f529a89
Source dataset
uspto-grants-1981_10
Patent number
US04294986

Reaction notes

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