Hydrochloric Acid → HCID 131712510, compound

HRID 848390Notes

Reaction equation

HRID 848390 reaction equation
C([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:25][O:26][CH:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[C:10]([NH:12][CH:13]2[C:23](=[O:24])[N:15]3[C:16]([C:20]([OH:22])=[O:21])=[CH:17][CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1)=O.Cl>CO.O1CCCC1>[NH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:25][O:26][CH:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[C:10]([NH:12][CH:13]2[C:23](=[O:24])[N:15]3[C:16]([C:20]([OH:22])=[O:21])=[CH:17][CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131712509HCID 131712509, compound

Product 1

HCID 131712510HCID 131712510, compoundYield 81.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

7-[2-(2-formamidothiazol-4-yl)-2cyclopentyloxyiminoacetamido]-3-cephem-4-carboxylic acid (syn isomer, 1.7 g.) in methanol (17 ml.) and tetrahydrofuran (5 ml.), and conc. hydrochloric acid (1.5 g.) were treated in a similar manner to that of Example 15-(3) to give 7-[2-(2-aminothiazol-4-yl)-2cyclopentyloxyiminoacetamido]-3cephem-4-carboxylic acid (syn isomer, 1.3 g.).

Sources & evidence

ORD record
ord-ee56aefb750d4b92b9df81dde0efbe62
Source dataset
uspto-grants-1981_10
Patent number
US04294960

Reaction notes

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