Hydrochloric Acid → HCID 178516179, compound

HRID 848720Notes

Reaction equation

HRID 848720 reaction equation
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:17]([O:19]C)=[O:18])[CH2:11][C:12]1[N:16]=[CH:15][NH:14][CH:13]=1)=[O:8].[OH-].[Na+].Cl>CO>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:17]([OH:19])=[O:18])[CH2:11][C:12]1[N:16]=[CH:15][NH:14][CH:13]=1)=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178501409HCID 178501409, compound

Product 1

HCID 178516179HCID 178516179, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5.6 g (0.02 mole) of pGlu-His-OMe are dissolved in 200 cc of MeOH and treated while cold for 2 hours with 4.8 g (6×0.02 mole) of NaOH. The solution which is obtained is acidified to pH 4.5 with 6×0.02 mole of HCl. After being evaporated to dryness under vacuum at 50° C., the pGlu-His-OH is obtained, and this can be used without any additional purification. White solid; yield is quantitative.

Workup

  1. customThe solution which is obtained
  2. customAfter being evaporated to dryness under vacuum at 50° C.

Sources & evidence

ORD record
ord-a4b42c020d9d4a54b4bdea09ec029a33
Source dataset
uspto-grants-1981_10
Patent number
US04297346

Reaction notes

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