Hydrochloric Acid → HCID 178522651, compound

HRID 848740Notes

Reaction equation

HRID 848740 reaction equation
N1C=CN=C1[C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:22][C:15]3[NH:16][C:17](=[S:21])[NH:18][C:19](=[O:20])[C:14]=3[CH2:13][C:12]=2[CH:23]=1)=[O:7].[NH2:24][C:25]1[NH:29][N:28]=[N:27][N:26]=1.O.Cl>CN(C)C=O>[NH:26]1[C:25]([NH:24][C:6]([C:8]2[CH:9]=[CH:10][C:11]3[O:22][C:15]4[NH:16][C:17](=[S:21])[NH:18][C:19](=[O:20])[C:14]=4[CH2:13][C:12]=3[CH:23]=2)=[O:7])=[N:29][N:28]=[N:27]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 20564194HCID 20564194, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178522651HCID 178522651, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Suspend 7-(imidazolylcarbonyl)-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione (0.6 g.) in dry dimethylformamide (20 ml.). With stirring, add 5-aminotetrazole (0.61 g.) and warm the mixture to 65°-75° C. and keep at that temperature for about 3/4 hour. Allow the mixture to cool, pour into water and acidify with hydrochloric acid. Filter and wash with isopropanol and ether to yield 7-(5-tetrazolylaminocarbonyl)-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione.

Workup

  1. temperaturewarm the mixture to 65°-75° C.
  2. waitkeep at that temperature for about 3/4 hour
  3. temperatureAllow the mixture to cool
  4. filtrationFilter
  5. washwash with isopropanol and ether

Sources & evidence

ORD record
ord-181abcc72cf34470b5d6cc50b1114115
Source dataset
uspto-grants-1981_10
Patent number
US04297355

Reaction notes

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