Hydrochloric Acid → HCID 20564183, compound

HRID 848741Notes

Reaction equation

HRID 848741 reaction equation
N1C=CN=C1[C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:22][C:15]3[NH:16][C:17](=[S:21])[NH:18][C:19](=[O:20])[C:14]=3[CH2:13][C:12]=2[CH:23]=1)=[O:7].[CH2:24]([NH2:28])[CH2:25][CH2:26][CH3:27].Cl>CN(C)C=O>[CH2:24]([NH:28][C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:22][C:15]3[NH:16][C:17](=[S:21])[NH:18][C:19](=[O:20])[C:14]=3[CH2:13][C:12]=2[CH:23]=1)=[O:7])[CH2:25][CH2:26][CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8007ButylamineHCID 20564194HCID 20564194, compound

Product 1

HCID 20564183HCID 20564183, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7-(Imidazolylcarbonyl)-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione (1 g.) is suspended in dry dimethylformamide (60 ml.) and n-butylamine (1.1 g.) is added. The mixture is stirred at room temperature overnight then at 70° C. for 11/2 hours. The product is added to dilute HCl and the solid is collected, washed with water, ethanol and ether and dried to yield the desired 7-(n-butylaminocarbonyl)-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione.

Workup

  1. customat 70° C.
  2. custom2 hours
  3. customthe solid is collected
  4. washwashed with water, ethanol and ether
  5. customdried

Sources & evidence

ORD record
ord-c1980e0a76594c45ba4ee7feefe04e0a
Source dataset
uspto-grants-1981_10
Patent number
US04297355

Reaction notes

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