Hydrochloric Acid → HCID 23264716, compound

HRID 849029Notes

Reaction equation

HRID 849029 reaction equation
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:10][C:11]1[C:16]([O:17][CH3:18])=[C:15]([O:19][CH3:20])[C:14]([O:21]C(=O)C)=[CH:13][C:12]=1[CH3:25])(=[O:9])[CH3:8].Cl>CO>[C:7]([O:10][C:11]1[C:12]([CH3:25])=[CH:13][C:14]([OH:21])=[C:15]([O:19][CH3:20])[C:16]=1[O:17][CH3:18])(=[O:9])[CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 23264933HCID 23264933, compound

Product 1

HCID 23264716HCID 23264716, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An aqueous solution (150 ml) of potassium carbonate (9.8 g) was added to a solution of 1,4-diacetoxy-5,6-dimethoxy-2-methylbenzene (31 g) in methanol (200 ml), and the mixture was stirred under an atmosphere of argon at room temperature for 1 hour. The reaction mixture was ice-cooled, made acidic by addition of hydrochloric acid (11 ml) and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the title compound (26 g, 90%) as an oil.

Workup

  1. temperaturecooled
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b79cf1e2e2c24117bb83eed214716340
Source dataset
uspto-grants-2000_01
Patent number
US06011046

Reaction notes

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