Water → HCID 12813906, compound

HRID 849153Notes

Reaction equation

HRID 849153 reaction equation
N1([C:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]=2)CCCC1.[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)=[CH2:13].[OH2:20]>COCCOCCOC>[N:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:12][CH2:13][CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1=[O:20]

Participants

5

Reactant 3

HCID 962WaterHCID 75212-VinylpyridineHCID 707681-Pyrrolidino-1-cyclohexene

Product 1

HCID 12813906HCID 12813906, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

Example 290 A) A sample of 1-Pyrrolidino-1-cyclohexene (7.1 mL, 44 mmol) and 2-vinylpyridine (4.3 mL, 40 mmol) were refluxed overnight in diglyme (100 mL). Water was then added and the mixture was stirred an additional 2 hours before extracting it with Et2O. The ether layer was dried over MgSO4 and concentrated in vacuo leaving an oil. The residue oil was distilled on a kugelrohr apparatus at 60-80° C. (0.1 mm) to give 2-(2-pyridyl) ethyl-2-cyclohexanone as a yellow oil (6.5 g).

Workup

  1. extractionbefore extracting it with Et2O
  2. dry with materialThe ether layer was dried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customleaving an oil
  5. distillationThe residue oil was distilled on a kugelrohr apparatus at 60-80° C. (0.1 mm)

Sources & evidence

ORD record
ord-603cd41444ae4920a26c6cf98c5e842e
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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