1H-Imidazole-4-carbaldehyde → HCID 178478530, compound

HRID 849393Notes

Reaction equation

HRID 849393 reaction equation
[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][N:8]2[C:14]3C=CC(C4C=CC=CC=4)=[CH:18][C:13]=3[CH2:12][N:11](C(C3C4C(=CC=CC=4)C=CC=3)=O)[CH2:10][CH2:9]2)[N:4]=[CH:3]1.Cl.N1C=C(CN2C3C=CC=CC=3CN(C([C:57]3[C:66]4[C:61](=[CH:62][CH:63]=[CH:64]C=4)[CH:60]=[CH:59][CH:58]=3)=O)CC2)N=C1.[CH:67]([C:69]1[N:70]=[CH:71][NH:72][CH:73]=1)=O.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl>[ClH:1].[ClH:1].[NH:72]1[CH:73]=[C:69]([CH2:67][N:11]2[C:12]3[CH:64]=[CH:63][C:62]([C:61]4[CH:66]=[CH:57][CH:58]=[CH:59][CH:60]=4)=[CH:18][C:13]=3[CH2:14][N:8]([CH2:7][C:5]3[N:4]=[CH:3][NH:2][CH:6]=3)[CH2:9][CH2:10]2)[N:70]=[CH:71]1

Participants

6

Reactant 4

HCID 764281H-Imidazole-4-carbaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 178479668HCID 178479668, compoundHCID 178479669HCID 178479669, compound

Product 1

HCID 178478530HCID 178478530, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Example 45 was prepared as an off white solid from Compound B of Example 12 as described for Compound D of Example 1, using methylene chloride as solvent, 4.3 equivalents of 4-formylimidazole, 4.3 equivalents of sodium triacetoxyborohydride and with stirring for 4 hours.

Sources & evidence

ORD record
ord-2a2548f2e67d46c08f9cdf0caaead780
Source dataset
uspto-grants-2000_01
Patent number
US06011029

Reaction notes

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