HRID849415

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85518

2-Thiophenesulfonyl chloride

C4H3ClO2S2

结构：CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2c[nH]cn2)C[C@H]1Cc1ccccc1.Cl

HCID178504910

未命名化合物

2 次

结构：CS(=O)(=O)N1Cc2cc(-c3ccccc3)ccc2N(Cc2c[nH]cn2)C[C@H]1Cc1cccnc1.Cl.Cl

HCID178504911

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.O=S(=O)(c1cccs1)N1Cc2cc(-c3ccccc3)ccc2N(Cc2c[nH]cn2)C[C@H]1Cc1cccnc1

HCID178478901

未命名化合物

PROCEDURE

实验过程

Example 329 was prepared as an off white solid from (R)-2,3,4,5-tetrahydro-7-phenyl-3-(3-pyridinylmethyl)-1H-1,4-benzodiazepine (prepared as described in Example 273) and 2-thiophenesulfonyl chloride by the following sequence: Compound C of Example 224; Compound D of Example 224. MS (M+H)+ 542.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c6b19c35c69144c6abfe590a79184ed3
来源数据集: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06011029
来源说明: uspto-grants-2000_01

反应 SMILES

[ClH:1].Cl.[NH:3]1[CH:7]=[C:6]([CH2:8][N:9]2[C:15]3[CH:16]=[CH:17][C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:19][C:14]=3[CH2:13][N:12]([S:26]([CH3:29])(=[O:28])=[O:27])[C@H:11]([CH2:30][C:31]3[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=3)[CH2:10]2)[N:5]=[CH:4]1.[S:37]1C=[CH:40][CH:39]=[C:38]1S([Cl:45])(=O)=O.Cl.BrC1C=CC2N(CC3N=CNC=3)C[C@@H](CC3C=CC=CC=3)N(S(C)(=O)=O)CC=2C=1>>[ClH:45].[ClH:1].[NH:3]1[CH:7]=[C:6]([CH2:8][N:9]2[C:15]3[CH:16]=[CH:17][C:18]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)=[CH:19][C:14]=3[CH2:13][N:12]([S:26]([C:29]3[S:37][CH:38]=[CH:39][CH:40]=3)(=[O:28])=[O:27])[C@H:11]([CH2:30][C:31]3[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=3)[CH2:10]2)[N:5]=[CH:4]1