2-Thiophenesulfonyl chloride → HCID 178478901, compound

HRID 849415Notes

Reaction equation

HRID 849415 reaction equation
[ClH:1].Cl.[NH:3]1[CH:7]=[C:6]([CH2:8][N:9]2[C:15]3[CH:16]=[CH:17][C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:19][C:14]=3[CH2:13][N:12]([S:26]([CH3:29])(=[O:28])=[O:27])[C@H:11]([CH2:30][C:31]3[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=3)[CH2:10]2)[N:5]=[CH:4]1.[S:37]1C=[CH:40][CH:39]=[C:38]1S([Cl:45])(=O)=O.Cl.BrC1C=CC2N(CC3N=CNC=3)C[C@@H](CC3C=CC=CC=3)N(S(C)(=O)=O)CC=2C=1>>[ClH:45].[ClH:1].[NH:3]1[CH:7]=[C:6]([CH2:8][N:9]2[C:15]3[CH:16]=[CH:17][C:18]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)=[CH:19][C:14]=3[CH2:13][N:12]([S:26]([C:29]3[S:37][CH:38]=[CH:39][CH:40]=3)(=[O:28])=[O:27])[C@H:11]([CH2:30][C:31]3[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=3)[CH2:10]2)[N:5]=[CH:4]1

Participants

4

Reactant 3

HCID 855182-Thiophenesulfonyl chlorideHCID 178504910(R)-7-Bromo-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-4-(methylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine, hydrochloride2×HCID 178504911HCID 178504911, compound

Product 1

HCID 178478901HCID 178478901, compound

Procedure

Example 329 was prepared as an off white solid from (R)-2,3,4,5-tetrahydro-7-phenyl-3-(3-pyridinylmethyl)-1H-1,4-benzodiazepine (prepared as described in Example 273) and 2-thiophenesulfonyl chloride by the following sequence: Compound C of Example 224; Compound D of Example 224. MS (M+H)+ 542.

Sources & evidence

ORD record
ord-c6b19c35c69144c6abfe590a79184ed3
Source dataset
uspto-grants-2000_01
Patent number
US06011029

Reaction notes

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