反应详情

温度

50 °C

To a solution of Example 389B (172 mg, 0.60 mmol) in N,N-dimethylformamide (1 mL) was added N-chlorosuccinimide (80 mg, 0.60 mmol). The mixture was heated at 50° C. for 2 hours and purified by reversed phase HPLC (0.1% trifluoroacetic acid(aq):acetonitrile) to afford the title compound with a shorter retention time than that of Example 392A.

1. custompurified by reversed phase HPLC (0.1% trifluoroacetic acid(aq):acetonitrile)