反应详情

[1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethyl]carbamic acid tertbutyl ester (2.4 g, 7.9 mmol) was dissolved in a saturated solution of hydrogen chloride in ethyl acetate (40 ml). After 5 h at 20° C. the reaction mixture was concentrated in vacuo. The residue was crystallized from ethyl acetate to give 2.05 g of (R) 1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride.

1. concentrationAfter 5 h at 20° C. the reaction mixture was concentrated in vacuo
2. customThe residue was crystallized from ethyl acetate