Hydrochloric Acid → HCID 18318408, compound

HRID 849831Notes

Reaction equation

HRID 849831 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:10]=[C:9]([CH:11]([NH:19]C(OC(C)(C)C)=O)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[O:8][N:7]=1)=[O:5])[CH3:2].[ClH:27]>C(OCC)(=O)C>[ClH:27].[CH2:1]([O:3][C:4]([C:6]1[N:10]=[C:9]([CH:11]([NH2:19])[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[O:8][N:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22949365HCID 22949365, compound

Product 1

HCID 18318408HCID 18318408, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-(1-tert-Butoxycarbonylamino-2-phenylethyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester (1.5 g, 4.2 mmol) was dissolved in a saturated solution of hydrogen chloride in ethyl acetate (40 ml). After 5 h at 20° C. the reaction mixture was concentrated in vacuo to give 1.2 g of (R) 5-(1-amino-2-phenylethyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester hydrochloride.

Workup

  1. concentrationAfter 5 h at 20° C. the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-2f525a7c37e84b5ea1f625481f56e7fa
Source dataset
uspto-grants-2000_01
Patent number
US06013658

Reaction notes

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