Hydrochloric Acid → 2-Phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride

HRID 850030Notes

Reaction equation

HRID 850030 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:16][C:10]=2[CH2:9]1)(OC(C)(C)C)=O.[ClH:23]>CCOC(C)=O>[ClH:23].[C:17]1([C:15]2[S:14][C:11]3[CH2:12][CH2:13][NH:8][CH2:9][C:10]=3[CH:16]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19365863N-Boc-2-phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Product 1

HCID 193658652-Phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

The product from Step 2 was dissolved in EtOAc at -25° C. and treated with HCl gas until saturated. The reaction was stoppered and stirred at 0° C. for 1 h. Removal of the solvent in vacuo afforded the title compound as a solid.

Workup

  1. customRemoval of the solvent in vacuo

Sources & evidence

ORD record
ord-63709392ff064df389811790be09d5cd
Source dataset
uspto-grants-2000_01
Patent number
US06015817

Reaction notes

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