Potassium Carbonate → HCID 18354600, compound

HRID 850046Notes

Reaction equation

HRID 850046 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[O:6].C(=O)([O-])[O-].[K+].[K+].[C:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Br)=[CH:21][CH:20]=1)#[N:18]>C(#N)C>[C:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23][O:1][C:2]2[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=2)[C:5]([NH2:7])=[O:6])=[CH:21][CH:20]=1)#[N:18]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 869964-(Bromomethyl)benzonitrileHCID 3424033-Hydroxybenzamide

Product 1

HCID 18354600HCID 18354600, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-hydroxybenzamide (0.137 g; 1 mmol) was dissolved in anhydrous acetonitrile (20 ml) under a nitrogen atmosphere. To this was added potassium carbonate (0.138 g; 1 mmol) and 4-cyanobenzyl bromide (0.138 g; 1 mmol). This was left to reflux for 5 hours.

Workup

  1. waitThis was left
  2. temperatureto reflux for 5 hours

Sources & evidence

ORD record
ord-f5d58c71bd6449a7bcbe6be1762c002b
Source dataset
uspto-grants-2000_01
Patent number
US06015827

Reaction notes

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