反应详情

To a solution of 33 mmol of 3-fluoro-4-bromo iodobenzene, 0.6 mmol of copper iodide and 1.1 mmol of dichlorobistriphenylphosphine palladium in 100 ml of diethylamine were added dropwise 33 mmol of 4-propyl phenylacetylene under an argon stream while stirring. After completion of the addition, the solution was stirred at room temperature for a further 2 hours and placed into water. The solution was extracted with heptane, washed with water and concentrated under reduced pressure to afford a brown oily product. The product was isolated and purified by a silica gel column chromatography to afford 33 mmol of 2-fluoro-4-[2-(4-propylphenyl)ethynyl]bromobenzene as a pale yellow oily product.

1. additionAfter completion of the addition
2. stirringthe solution was stirred at room temperature for a further 2 hours
3. extractionThe solution was extracted with heptane
4. washwashed with water
5. concentrationconcentrated under reduced pressure
6. customto afford a brown oily product
7. customThe product was isolated
8. custompurified by a silica gel column chromatography