Hydrochloric Acid → HCID 70102972, compound

HRID 850312Notes

Reaction equation

HRID 850312 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH:14]=[C:15]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][CH2:19][O:18][C:17]3[CH:27]=[CH:28][CH:29]=[CH:30][C:16]2=3)[CH2:7]1)=[O:5])[CH3:2].[ClH:31].CCOCC>O1CCCC1>[ClH:31].[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH:14]=[C:15]2[C:16]3[CH:30]=[CH:29][CH:28]=[CH:27][C:17]=3[O:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]2=3)[CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 70102673HCID 70102673, compound

Product 1

HCID 70102972HCID 70102972, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(R)-1-(3-(12H-dibenzo[d,g][1,3]dioxocin-12-ylidene)-1-propyl)-3-piperidinecarboxylic acid ethyl ester (0.86 g, 2.1 mmol, prepared as described in example 2 was dissolved in tetrahydrofuran (10 ml) and a 2.6 N solution of hydrogen chloride in ether (0.97 ml, 2.52 mmol) was added dropwise. The solution was evaporated in vacuo and the remainder was treated with ether (20 ml). The precipitate was filtered off, washed with ether and dried in vacuo, affording the title compound as a powder.

Workup

  1. customThe solution was evaporated in vacuo
  2. additionthe remainder was treated with ether (20 ml)
  3. filtrationThe precipitate was filtered off
  4. washwashed with ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-1d49f4c8b5ec4e1c9f7db3b3b570e3be
Source dataset
uspto-grants-2000_01
Patent number
US06017915

Reaction notes

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