Thiophenol → HCID 178422816, compound

HRID 850393Notes

Reaction equation

HRID 850393 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([OH:9])[C:3]=1[N+:10]([O-:12])=[O:11].CCN(CC)CC.[C:20]1([SH:26])[CH:25]=[CH:24][CH:23]=CC=1>CCO>[OH:9][C:4]1[C:3]([N+:10]([O-:12])=[O:11])=[C:2]([C:23]2[S:26][CH:20]=[CH:25][CH:24]=2)[CH:7]=[C:6]([CH3:8])[N:5]=1

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 8471TriethylamineHCID 178426130HCID 178426130, compound

Product 1

HCID 178422816HCID 178422816, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-chloro-2-hydroxy-6-methyl-3-nitropyridine (188 mg, 1.0 mmol) in 2 mL of EtOH and 0.2 mL (1.4 mmol) of Et3N was added 0.11 mL (1.0 mmol) of PhSH. Precipitation occurred immediately and the solution was allowed to stir at room temperature for 16 h. The solid was filtered and washed with EtOH to afford II-2.

Workup

  1. customPrecipitation
  2. filtrationThe solid was filtered
  3. washwashed with EtOH
  4. customto afford II-2

Sources & evidence

ORD record
ord-361d61b183324095a30205a8582564f6
Source dataset
uspto-grants-2000_01
Patent number
US06017934

Reaction notes

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