反应详情

温度

90 °C

Dimethyl 4-hydroxyphthalate (10.0 g, 47 mmol) was dissolved in DMF (100 ml), and potassium carbonate (30 g, 217 mmol) and n-amyl bromide (10 ml, 80 mmol) were added to this solution. The mixture was stirred at 90° C. for 2 hours, and the solid was removed by filtration through Celite. The filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (hexane/ethyl acetate=4/1) to give dimethyl 4-pentyloxyphthalate (12.7 g, 45.4 mmol, 97%) as a colorless oil.

1. customthe solid was removed by filtration through Celite
2. concentrationThe filtrate was concentrated under reduced pressure
3. customThe obtained residue was purified by column chromatography on silica gel (hexane/ethyl acetate=4/1)