反应详情

A warm solution of 1.0 g. of 4-[N-(carbobenzyloxy)-N-hexadecylamino]-2-thiophenecarbonyl chloride and 1.3 g. of triethylamine in 100 ml. of ether is added to 1.2 g. of pyrrolidine. A precipitate forms; the mixture is stirred under reflux for 1 hour, filtered, and extracted with hot ether. The extract is evaporated and a solution of the resulting residue in 100 ml. of tetrahydrofuran is shaken under 50 psi of hydrogen in the presence of 0.6 g. of 10% palladium on carbon. The mixture is filtered and the filtrate evaporated. The residue is crystallized from acetic acid to yield the product as a white solid.

1. temperatureunder reflux for 1 hour
2. filtrationfiltered
3. extractionextracted with hot ether
4. customThe extract is evaporated
5. stirringof tetrahydrofuran is shaken under 50 psi of hydrogen in the presence of 0.6 g
6. filtrationThe mixture is filtered
7. customthe filtrate evaporated
8. customThe residue is crystallized from acetic acid