Methyl Isocyanate → N-methyl-carbamic acid O-(1-iso-propylpyrazol-4-yl) ester
Reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[CH:5]([N:8]1[CH:12]=[C:11]([OH:13])[CH:10]=[N:9]1)([CH3:7])[CH3:6]>CC(C)=O.C(N(CC)CC)C>[CH:5]([N:8]1[CH:12]=[C:11]([O:13][C:3](=[O:4])[NH:2][CH3:1])[CH:10]=[N:9]1)([CH3:7])[CH3:6]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 45 °C
Procedure
6 g (0.105 mol) of methyl isocyanate were added to a solution of 12.6 g (0.1 mol) of 1-isopropyl-4-hydroxy-pyrazole in 100 ml of acetone and 2 drops of triethylamine. The mixture was stirred at 45° C. for 12 hours and the solvent was then distilled off in vacuo. 17.4 g (95% of theory) of N-methyl-carbamic acid O-(1-iso-propylpyrazol-4-yl) ester were thus obtained in the form of beige crystals with a melting point of 40° C.
Workup
- distillationthe solvent was then distilled off in vacuo
Sources & evidence
- ORD record
- ord-d3a9672dd9d346b18070dfedfc708c8a
- Source dataset
- uspto-grants-1983_05
- Patent number
- US04382947
Reaction notes
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