Hydrochloric Acid → HCID 86653791, compound

HRID 85119Notes

Reaction equation

HRID 85119 reaction equation
CC1(C)[O:6][CH:5]([CH2:7][O:8][C:9]2[CH:10]=[C:11]([C:15]3[NH:19][C:18]4[CH:20]=[CH:21][CH:22]=[C:23]([C:24]([NH:26][C:27]5[S:28][CH:29]=[CH:30][N:31]=5)=[O:25])[C:17]=4[N:16]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:4][O:3]1.Cl>C1COCC1>[OH:6][CH:5]([CH2:4][OH:3])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([C:15]2[NH:19][C:18]3[CH:20]=[CH:21][CH:22]=[C:23]([C:24]([NH:26][C:27]4[S:28][CH:29]=[CH:30][N:31]=4)=[O:25])[C:17]=3[N:16]=2)[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86653792HCID 86653792, compound

Product 1

HCID 86653791HCID 86653791, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)-N-(thiazol-2-yl)-1H-benzo[d]imidazole-4-carboxamide (37; 50 mg, 0.111 mmol) in THF was added 4N HCl dropwise until precipitation was observed. The precipitate was collected via vacuum filtration and washed with anhydrous ethanol. The product (Compound 324) was dried overnight under vacuum. (Product was pale yellowish in color and yield=86%). MS (ESI) calcd for C23H22N4O4S: 410.10; found: 411 [M+H].

Workup

  1. customdropwise until precipitation
  2. filtrationThe precipitate was collected via vacuum filtration
  3. washwashed with anhydrous ethanol
  4. dry with materialThe product (Compound 324) was dried overnight under vacuum

Sources & evidence

ORD record
ord-bf3af73807d14066aa47e23755b981ec
Source dataset
uspto-grants-2014_09
Patent number
US08846947B2

Reaction notes

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