Chloroacetone → HCID 13136936, compound

HRID 851203Notes

Reaction equation

HRID 851203 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]2[C:11]3[CH2:16][CH2:15][NH:14][CH2:13][C:12]=3[C:17](=[O:19])[O:18][C:4]=2[CH:3]=1.C(N(CC)CC)C.Cl[CH2:28][C:29](=[O:31])[CH3:30]>>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]2[C:11]3[CH2:16][CH2:15][N:14]([CH2:28][C:29](=[O:31])[CH3:30])[CH2:13][C:12]=3[C:17](=[O:19])[O:18][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 13136924HCID 13136924, compound

Product 1

HCID 13136936HCID 13136936, compoundYield 35.6%

Procedure

Prepared by the method described for example 26 from 1,2,3,4-tetrahydro-8-methyl-9-nitro-5H-[1]benzopyrano[3,4-c]pyridin-5-one (2.0 g, 0.008 moles), triethylamine (2.3 ml, 0.017 moles), and 1-chloro-2-propanone (0.7 g, 0.008 moles). Recrystallization from methanol gave the product (0.9 g), mp 166°-168° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from methanol

Sources & evidence

ORD record
ord-1322b18f4a2b418a9a54a3ba6e2bcffe
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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