反应详情

温度

0 °C

A mixture of [ethoxy(4-phenylbutyl)phosphinyl]acetic acid (1.71 g), acetonitrile and carbonyldiimidazole (0.97 g) is stirred under argon at 0° C. for 1 hour. (S)-4-hydroxyproline, methyl ester (0.006 mole) is suspended in acetonitrile, added to the mixture and stirred at room temperature 90 minutes. Solvent is stripped off, and the resulting oil is taken up in ethyl acetate, washed with 5% potassium bisulfate, washed with saturated sodium bicarbonate, washed with brine, dried over magnesium sulfate, and the solvent stripped to leave 2.23 g of the title compound as an oil.

1. additionadded to the mixture
2. stirringstirred at room temperature 90 minutes
3. washwashed with 5% potassium bisulfate
4. washwashed with saturated sodium bicarbonate
5. washwashed with brine
6. dry with materialdried over magnesium sulfate