Sodium Carbonate → HCID 135672568, compound

HRID 851479Notes

Reaction equation

HRID 851479 reaction equation
Br[CH:2]([C:7](=[O:15])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[CH2:3][C:4]([O-:6])=[O:5].[OH:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH2:23])=[S:22])=[CH:19][CH:18]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2([OH:15])[CH:2]([CH2:3][C:4]([OH:6])=[O:5])[S:22][C:21]([C:20]3[CH:24]=[CH:25][C:17]([OH:16])=[CH:18][CH:19]=3)=[N:23]2)=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 27593444-HydroxythiobenzamideHCID 78246224HCID 78246224, compound

Product 1

HCID 135672568HCID 135672568, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-Bromo-3-(4-chlorobenzoyl)propionate acid and an equimolar amount of 4-hydroxythio-benzamide are stirred in isopropyl alcohol solvent containing sodium carbonate to give 4-(4-chlorophenyl)-4-hydroxy-2-(4-hydroxyphenyl)-2-thiazolin-5-acetic acid. This compound is dehydrated by heating to give the title compound.

Sources & evidence

ORD record
ord-7b91b82d317b4956a83fd968adaea952
Source dataset
uspto-grants-1983_05
Patent number
US04385059

Reaction notes

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