Triethylamine → HCID 54385324, compound

HRID 851658Notes

Reaction equation

HRID 851658 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1.C(N(CC)CC)C.[F:28][C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:33](=[O:34])[C:32]1[CH:36]=[CH:37][C:29]([F:28])=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 678794-Fluorobenzoyl chlorideHCID 130258148-(4-Methoxyphenylamino)-caprylic acid methyl ester

Product 1

HCID 54385324HCID 54385324, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

As described in example 3(b), the reaction is carried out with 5.6 g (20 mmol) of 8-(4-methoxyphenylamino)-caprylic acid methyl ester, 5 g (50 mmol) of triethylamine, 150 cc. of toluene and 4 g (25 mmol) of 4-fluorobenzoic acid chloride. Reaction time: 5 hours, reaction temperature: 25° C. The crude product is used in the next reaction step without further purification.

Workup

  1. customReaction time
  2. custom5 hours, reaction temperature
  3. custom25° C

Sources & evidence

ORD record
ord-95c3342db8e0489a82a233324c991fa8
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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