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HRID85167

反应详情

EQUATION

反应方程式

HRID 85167 的结构方程式

REACTANTS

反应物

2
结构：Cc1cnc(N)s1
HCID351770

2-Amino-5-methyl-thiazole

C4H6N2S

结构：O=C(O)c1cccc2[nH]c(-c3cnccc3C(F)(F)F)nc12
HCID67201470

2-[4-(Trifluoromethyl)-3-pyridinyl]-1H-benzimidazole-7-carboxylic acid

C14H8F3N3O2

PRODUCTS

生成物

1
结构：Cc1cnc(NC(=O)c2cccc3[nH]c(-c4cnccc4C(F)(F)F)nc23)s1
HCID58279251

未命名化合物

PROCEDURE

实验过程

2-(4-(Trifluoromethyl)pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid 119 was coupled to 2-amino-5-methylthiazole 171 using the same general amide coupling procedure shown above to afford N-(5-methylthiazol-2-yl)-2-(4-(trifluoromethyl)pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxamide (Compound 703). MS (ESI) calcd for C18H12F3N5OS: 403.07; found: 404 [M+H].