反应详情

4.12 g (12.5 mmoles) of BOC-Nva-Leu-NH2 are suspended in 15 ml of ethyl acetate, and 20 ml of a 6 n hydrochloric acid solution in ethyl acetate are added to the suspension. After one hour of standing the reaction mixture is diluted with ether, the separated precipitate is filtered off, and the resulting 3.64 g of crude product is recrystallized from 25 ml of methanol. 2.75 g (83%) of H-Nva-Leu-NH2.HCl are obtained; m.p.: 215°-216° C., Rf5 =0.45, [α]D25 =-3.47° (c=1%, in methanol).

1. filtrationthe separated precipitate is filtered off
2. customthe resulting 3.64 g of crude product is recrystallized from 25 ml of methanol