Chloroacetone → HCID 11448585, compound

HRID 851877Notes

Reaction equation

HRID 851877 reaction equation
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][S:9](=[O:11])(=[O:10])[C:5]=2[CH:4]=1.[H-].[Na+].Cl[CH2:18][C:19](=[O:21])[CH3:20]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[N:8]([CH2:18][C:19](=[O:21])[CH3:20])[S:9](=[O:11])(=[O:10])[C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 6571ChloroacetoneHCID 24758Sodium hydrideHCID 110747271,2-BENZISOTHIAZOL-3(2H)-ONE, 6-METHOXY, 1,1-DIOXIDE

Product 1

HCID 11448585HCID 11448585, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

360 mg of 6-methoxy-1,1-dioxo-1,2-dihydro-benzo[d]isothiazol-3-one are added in small portions to a suspension of 72 mg of 60% NaH in mineral oil in 1.6 ml of anhydrous dimethylformamide. After stirring for 30 min. at ambient temperature, the reaction mixture becomes homogeneous and 162 μl of chloroacetone are added thereto. The reaction mixture is heated at 110° C. for 30 min. It is allowed to return to ambient temperature, and then the mixture is precipitated by addition of water. The precipitate is filtered off, rinsed several times with water, suction-filtered off and dried in vacuo.

Workup

  1. temperatureThe reaction mixture is heated at 110° C. for 30 min
  2. customto return to ambient temperature
  3. customthe mixture is precipitated by addition of water
  4. filtrationThe precipitate is filtered off
  5. washrinsed several times with water
  6. filtrationsuction-filtered off
  7. customdried in vacuo

Sources & evidence

ORD record
ord-00a99096349849d78a777ca659d464d3
Source dataset
uspto-grants-2007_08
Patent number
US07253161B2

Reaction notes

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