Hydrazine hydrate (1:1) → HCID 69414151, compound

HRID 851891Notes

Reaction equation

HRID 851891 reaction equation
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16](OC)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.O.[NH2:28][NH2:29]>CO.CN(C=O)C>[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([NH:28][NH2:29])=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 69414424HCID 69414424, compound

Product 1

HCID 69414151HCID 69414151, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

A suspension of 500 mg (1.34 mmol) of the product obtained in Step A and 978 μl (20.13 mmol) of hydrazine monohydrate in a mixture of MeOH (30 ml) and DMF (6 ml) is refluxed for 24 hours. The MeOH is evaporated off, water is added to the reaction mixture and the precipitate, which corresponds to the title product, is filtered off.

Workup

  1. temperatureis refluxed for 24 hours
  2. customThe MeOH is evaporated off
  3. additionwater is added to the reaction mixture
  4. filtrationis filtered off

Sources & evidence

ORD record
ord-862ff0c4f81b44cbb184e5c07dd910c3
Source dataset
uspto-grants-2007_08
Patent number
US07253163B2

Reaction notes

Loading…