反应详情

2.51 ml (18.0 mmol) of triethylamine are added to a solution of 1.25 g (18.0 mmol) of hydroxylamine hydrochloride in 4 ml of DMSO and the suspension is stirred for 10 minutes. The precipitate is filtered off and the filtrate is concentrated. 992 mg (3.00 mmol) of the product of Step A of Example 27 are added to the filtrate and the solution is stirred at 75° C. for 1 hour 30 minutes. The solution is allowed to return to ambient temperature, and precipitation of the reaction mixture is brought about using water. The precipitate is filtered off to yield the title product.

1. filtrationThe precipitate is filtered off
2. concentrationthe filtrate is concentrated
3. stirringthe solution is stirred at 75° C. for 1 hour 30 minutes
4. customto return to ambient temperature
5. customprecipitation of the reaction mixture
6. filtrationThe precipitate is filtered off