Hydrochloric Acid → HCID 69507741, compound

HRID 851982Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[CH:24][C:23]=2[F:30])[C@@H:13]2[CH2:19][CH2:18][CH2:17][CH2:16][NH:15][C:14]2=[O:20])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH2:31]([OH:33])[CH3:32]>>[ClH:2].[CH2:31]([O:33][C:28](=[NH:29])[C:25]1[CH:26]=[CH:27][C:22]([CH2:21][N:12]([S:9]([C:6]2[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=2)(=[O:10])=[O:11])[C@@H:13]2[CH2:19][CH2:18][CH2:17][CH2:16][NH:15][C:14]2=[O:20])=[C:23]([F:30])[CH:24]=1)[CH3:32]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 69490966HCID 69490966, compound

Product 1

HCID 69507741HCID 69507741, compound

Procedure

Dry HCl gas was slowly bubbled through a solution of 4-chloro-N-(4-cyano-2-fluoro-benzyl)-N-((R)-2-oxo-azepan-3-yl)-benzenesulfonamide (0.09 g, 0.20 mmol) in dry ethanol (3 ml) for 30 min at 0° C. The reaction mixture wa allowed to stir for a further 20 h at r.t. and then concentrated under reduced pressure. Trituration of the residue in diethyl ether yielded the HCl salt: 0.09 g; MS: m/e=482.2 (MH+).

Workup

concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-51e3ac5ad01a4eff9239de32919e1f06
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253158B2

Reaction notes

Loading…