反应详情

4-Chloro-N-(2-oxo-azepan-3-yl)-benzenesulfonamide (0.16 g, 0.52 mmol), 1-[4-(bromomethyl)phenyl]-1H-1,2,4-triazol (0.25 g, 1.03 mmol), potassium carbonate (0.72 g, 5.17 mmol) and potassium iodide (0.02 g, 0.10 mmol) in 5 ml dimethylformamide were stirred at 65° C. for 5 hours. Extraction with water/ethylacetate and chromatography on silicagel with ethylacetate yielded 0.15 g (64%) 4-chloro-N-(2-oxo-azepan-3-yl)-N-(4-[1,2,4]triazol-1-yl-benzyl)-benzenesulfonamide as white solid, MS: m/e (%)=460.1 (MH+, 100).

1. extractionExtraction with water/ethylacetate and chromatography on silicagel with ethylacetate