反应详情

温度

80 °C

62 g (121 mmol) of the compound from Example 15A are dissolved in 2 l of a 1:1 mixture of ethanol and ethyl acetate, and 46 g (726 mmol) of ammonium formate and 0.6 g of palladium on carbon are added. The mixture is heated at 80° C. After 45 min, the mixture is allowed to cool and filtered through silica gel. The filter cake is washed with ethyl acetate and the filtrate is evaporated to dryness under reduced pressure. This gives 36 g (61% of theory) of the desired product.

1. additionare added
2. temperatureto cool
3. filtrationfiltered through silica gel
4. washThe filter cake is washed with ethyl acetate
5. customthe filtrate is evaporated to dryness under reduced pressure