1,3-Dibromopropane → 1-(3-Bromopropyl)piperidine

HRID 852093Notes

Reaction equation

HRID 852093 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:7][CH2:8][CH2:9][CH2:10]Br.C(=O)([O-])[O-].[Na+].[Na+]>O>[Br:7][CH2:8][CH2:9][CH2:10][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 80011,3-DibromopropaneHCID 8082PiperidineHCID 10340Sodium Carbonate

Product 1

HCID 130340461-(3-Bromopropyl)piperidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Combine piperidine (5.0 g, 58.7 mmol), fused sodium acetate (4.82 g, 58.7 mmol) and 1,3-dibromopropane (11.85 g, 58.7 mmol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,3-dibromopropane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound.

Workup

  1. customRemove the unreacted 1,3-dibromopropane
  2. distillationby distillation
  3. extractionExtract the left-over residue with ether
  4. customevaporate

Sources & evidence

ORD record
ord-2b13a16a6c9d4d78856a320ca8b39478
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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