Potassium Iodide → HCID 69419679, compound

HRID 852098Notes

Reaction equation

HRID 852098 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:16]3[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=3[O:14][N:13]=2)=[CH:8][CH:7]=1.[ClH:22].[NH2:23][CH:24]1[CH2:32][C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[ClH:22].[F:21][C:19]1[CH:18]=[CH:17][C:16]2[C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][NH:23][CH:24]4[CH2:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH2:25]4)=[CH:7][CH:8]=3)=[N:13][O:14][C:15]=2[CH:20]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium Carbonate2×HCID 1227642-Aminoindan hydrochlorideHCID 17906346HCID 17906346, compound

Product 1

HCID 69419679HCID 69419679, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from a mixture of 3-[4-(3-bromo-propoxy)-phenyl]-6-fluoro-benzo[d]isoxazole, 2-aminoindan hydrochloride, potassium carbonate, potassium iodide and 4% aqueous acetonitrile essentially as described above in Example 13 except that 3.2 equivalents of potassium carbonate is used. Purity by LC/MS=93%, [M+H]+=403.

Sources & evidence

ORD record
ord-ef60311cc5e04492816f8aa6fea79faf
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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