Potassium Iodide → HCID 58928261, compound

HRID 852103Notes

Reaction equation

HRID 852103 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:16]3[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=3[O:14][N:13]=2)=[CH:8][CH:7]=1.Cl.[S:23]1[CH:27]=[CH:26][C:25](NC)=[CH:24]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[C:38](#[N:40])C>>[F:21][C:19]1[CH:18]=[CH:17][C:16]2[C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][NH:40][CH2:38][C:25]4[CH:26]=[CH:27][S:23][CH:24]=4)=[CH:7][CH:8]=3)=[N:13][O:14][C:15]=2[CH:20]=1

Participants

6

Reactant 5

HCID 4875Potassium IodideHCID 6342AcetonitrileHCID 11430Potassium Carbonate2×HCID 17906346HCID 17906346, compoundHCID 21218568HCID 21218568, compound

Product 1

HCID 58928261HCID 58928261, compound

Procedure

The title compound is prepared from a mixture of 3-[4-(3-bromo-propoxy)-phenyl]-6-fluoro-benzo[d]isoxazole, thiophen-3-yl-methylamine hydrochloride (Table No. 1, SM 1), potassium carbonate, potassium iodide and 4% aqueous acetonitrile essentially as described above in Example 13 except that 3.2 equivalents of potassium carbonate is used. Purity by LC/MS=95%, [M+H]+=383.

Sources & evidence

ORD record
ord-bae6a17f34b74d4993e8bb756511feb2
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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