反应详情

25 g (48 mmol) of the compound from Example 31A are dissolved in 500 ml of ethyl acetate and 500 ml of ethanol. 18 g (286 mmol) of ammonium formate and 1 g of palladium on carbon are added, and the mixture is heated at reflux for 45 min. The reaction solution is then allowed to cool and filtered through silica gel. The filtrate is concentrated to dryness under reduced pressure. This gives 25 g (100% of theory) of the desired product.

1. temperaturethe mixture is heated
2. temperatureat reflux for 45 min
3. temperatureto cool
4. filtrationfiltered through silica gel
5. concentrationThe filtrate is concentrated to dryness under reduced pressure