Dimethylformamide → HCID 58928275, compound

HRID 852167Notes

Reaction equation

HRID 852167 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.C[N:23]([CH3:26])C=O>C1(CCN)CCCCC=1.C(O)C>[C:5]1([CH2:6][CH2:26][NH:23][CH2:19][C@@H:17]([OH:18])[CH2:16][O:15][C:12]2[CH:11]=[CH:10][C:9]([C:6]3[C:5]4[CH:20]=[CH:21][C:2]([F:1])=[CH:3][C:4]=4[O:8][N:7]=3)=[CH:14][CH:13]=2)[CH2:20][CH2:21][CH2:2][CH2:3][CH:4]=1

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 58928275HCID 58928275, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 769382-(1-Cyclohexenyl)ethylamineSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 2-(1-cyclohexenyl)ethylamine in ethanol, essentially as described above in Example 70. Purity by LC/MS=100%, [M+H]+=411.

Sources & evidence

ORD record
ord-89f7447c4d7649f1a9ae801c642e4e5a
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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