(1S,2R)-(-)-1-Amino-2-indanol → HCID 69416792, compound

HRID 852168Notes

Reaction equation

HRID 852168 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH2:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C@H:24]([NH2:31])[C@@H:23]1[OH:32]>CN(C)C=O.C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:10]=[CH:11][C:12]([O:15][CH2:16][CH:17]([OH:18])[CH2:19][NH:31][C@@H:24]4[C:25]5[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=5)[CH2:22][CH:23]4[OH:32])=[CH:13][CH:14]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 9866743(1S,2R)-(-)-1-Amino-2-indanolHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 69416792HCID 69416792, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and (1S, 2R)-(−)-cis-1-amino-2-indanol in ethanol, essentially as described above in Example 70. Purity by LC/MS=100%, [M+H]+=435.

Sources & evidence

ORD record
ord-298e3a2bc64848bfaa3da9755f627f39
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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