1,2,3,4-Tetrahydroisoquinoline → HCID 58928276, compound

HRID 852204Notes

Reaction equation

HRID 852204 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[S:15][CH:16]=2)=[CH:8][CH:7]=1.[CH2:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23][NH:22]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[S:15]1[CH:16]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:22]3[CH2:23][CH2:24][C:25]4[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:21]3)=[CH:7][CH:8]=2)[C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]1=2

Participants

5

Reactant 3

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 11430Potassium CarbonateHCID 179063143-[4-(3-Bromo-propoxy)-phenyl]-benzo[b]thiophene

Product 1

HCID 58928276HCID 58928276, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from 3-[4-(3-bromo-propoxy)-phenyl]-benzo[b]thiophene, 1,2,3,4-tetrahydroisoquinoline, potassium carbonate and acetonitrile essentially as described above in Example 118. Purity by LC/MS=94%, [M+H]+=400.

Sources & evidence

ORD record
ord-c012ea1441514fd09482ece01fd112d6
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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