2-Nitrobenzenesulfonyl chloride → 2-(4-methylpiperazine-1-sulfonyl)phenylamine

HRID 852236Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N+:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17](Cl)(=[O:19])=[O:18])([O-])=O>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:17]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[NH2:8])(=[O:19])=[O:18])[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 155402-Nitrobenzenesulfonyl chloride

HCID 531671-Methylpiperazine

Product 1

HCID 11328152-(4-methylpiperazine-1-sulfonyl)phenylamineYield 80%

Procedure

The title compound (2.1 g, 80%) was obtained as a white solid from N-methylpiperazine and 2-nitrobenzenesulfonyl chloride following the same procedure as described in Preparation 2.

Sources & evidence

ORD record: ord-bc043e2516f14b749b287af20dee50c7
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253171B2

Reaction notes

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