Hydrochloric Acid → HCID 69376868, compound

HRID 852249Notes

Reaction equation

HRID 852249 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:29])[C@@H:5]([NH:21]C(OC(C)(C)C)=O)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1>O1CCOCC1>[ClH:1].[CH3:2][O:3][C:4](=[O:29])[C@@H:5]([NH2:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21063260HCID 21063260, compound

Product 1

HCID 69376868HCID 69376868, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

3 ml of a saturated solution of HCl in dioxane were added to a solution of (S)-2-tert-butoxycarbonylamino-3-(2′-cyano-biphenyl-4-yl) propionic acid methyl ester (513 mg, 1.35 mmol) in dioxane (4 ml) and the resulting mixture was stirred at room temperature for 3 h. The solvent was concentrated in vacuo to yield the title compound (425 mg, 99%) that was used in the next step without further purification.

Workup

  1. concentrationThe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-8723890f740a411ab5a5f11e62ce2dd7
Source dataset
uspto-grants-2007_08
Patent number
US07253171B2

Reaction notes

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