4-Aminophenol → HCID 57438531, compound

HRID 852263Notes

Reaction equation

HRID 852263 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13](Cl)[CH:12]=1.CC([O-])(C)C.[K+].C1OCCOCCOCCOCCOCCOC1.CC(N(C)C)=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:13]2[CH:12]=[C:11]([O:10][CH3:9])[CH:16]=[CH:15][N:14]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 4034-AminophenolHCID 19911282-Chloro-4-methoxypyridineHCID 131726544HCID 131726544, compound

Product 1

HCID 57438531HCID 57438531, compound

Procedure

4-Aminophenol was reacted with 4-methoxy-2-chloropyridine in the presence of KOtBu/18-Crown-6/DMA at 150° C. for 5 hrs to give 2-(4-aminophenoxy)-4-methoxypyridine. The product was purified by chromatography.

Sources & evidence

ORD record
ord-838e23abdcf642e493a9dd9a2fbc274b
Source dataset
uspto-grants-2007_08
Patent number
US07253184B2

Reaction notes

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