反应详情

温度

0 °C

To a solution of 4-methoxypyridine (50 mL, 0.492 mol) in toluene (1 L) is added benzyl chloroformate (70.3 mL, 0.492 mol) at 0° C. The resulting mixture is stirred at 0° C. for 30 minutes then cooled to −75° C. and allyl magnesium chloride (295.5 mL, 0.591 mol) is added. The solution is held at −75° C. for 4 hours and allowed to warm to 0° C. at which point a solution of 20% HCl is added to quench the reaction. The organic layer is isolated and purified over silica gel to yield the desired product.

1. temperaturethen cooled to −75° C.
2. waitThe solution is held at −75° C. for 4 hours
3. additionis added
4. customto quench
5. customthe reaction
6. customThe organic layer is isolated
7. custompurified over silica gel